Home A Genetic Switch An Introduction to Nervous Systems Epigenetics From a to α Genes and Signals Transcriptional Regulation Help


Subject Areas: Genetics and Genome Science; Molecular Biology

Edited By: C. David Allis, The Rockefeller University, New York; Thomas Jenuwein, Research Institute of Molecular Pathology, Vienna; Danny Reinberg, Howard Hughes Medical Institute/University of Medicine and Dentistry of New Jersey‐Robert Wood Johnson Medical School; Marie-Laure Caparros, Associate Editor

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The regulation of gene expression in many biological processes involves epigenetic mechanisms. In this new volume, 24 chapters written by experts in the field discuss epigenetic effects from many perspectives. There are chapters on the basic molecular mechanisms underpinning epigenetic regulation, discussion of cellular processes that rely on this kind of regulation, and surveys of organisms in which it has been most studied. Thus, there are chapters on histone and DNA methylation, siRNAs and gene silencing; X-chromosome inactivation, dosage compensation and imprinting; and discussion of epigenetics in microbes, plants, insects, and mammals. The last part of the book looks at how epigenetic mechanisms act in cell division and differentiation, and how errors in these pathways contribute to cancer and other human diseases. Also discussed are consequences of epigenetics in attempts to clone animals. This book is a major resource for those working in the field, as well as being a suitable text for advanced undergraduate and graduate courses on gene regulation.

review:  “The historical accounts of the rise of epigenetics as a field of study, combined with the inclusion of cutting-edging epigenetics research in various biological processes and model organisms, provide the reader with a clear sense of what epigenetics research is about, where it came from, where it is now, and where it is headed. It will prove to be the book that everyone with an interest in epigenetics would want to have and read.”

review:  “As a whole, Epigenetics is an impressive volume. The contributors provide an accurate survey of the field, from where it began, through where it is today, to where it is heading. Their accounts help set the stage for deepening our understanding of epigenetic phenomena and mechanisms. And the volume will undoubtedly prove to be very useful for students and researchers alike.”

review:  “Overall, Epigenetics is a scholarly work, eminently readable and a welcome resource for anyone looking for an introduction to this new and vibrant field.”

review:  “Beautifully illustrated, this book is a rich source of information for a diverse pool of readers, ranging from graduate students making their first steps in a new field of knowledge to more experienced scientists whose research has led them to unfamiliar grounds.

...what makes “Epigenetics” a truly remarkable and, I believe, a long–lasting achievement is the clear and accessible overview of the major concepts and mechanisms that lay in the foundation of contemporary chromatin research. New details of how specific enzymes and proteins shape chromatin structure and composition may emerge, but the general principles that define how chromatin impacts on many cellular processes are likely to hold true.”
      —Genetical Research

review:  “In addition to the cutting–edge epigenetic research that is highlighted in this book by eminent scientists in the field, the summaries at the beginning of each chapter, and the multiple tables and colourful illustrations used throughout the book will prove useful in guiding the reader through a discussion of complex biological processes. Undoubtedly, some of these illustrations will be widely used by students and teacher of epigenetics. It is evident that the importance of epigenetics has become widely recognized and this book will be an excellent read for beginners as well as experts in this field.”
      —Nature Cell Biology

review:  “What is epigenetics? Asking that question will likely return a number of answers that are all some variation of ‘heredity that is not due to changes in DNA sequence.’ In other words, epigenetics is not genetics. That seems a definition as indistinct as U.S. Supreme Court Justice Potter Stewart’s statement, ‘I know it when I see it,’ about obscenity. The recent volume, Epigenetics, provides well-needed clarity by setting down the fundamental concepts and principles of this emerging science...

With the publication of Epigenetics, this fascinating scientific field no longer needs to be defined by what it is not.”
      —The Quarterly Review of Biology

C. David Allis is the Joy and Jack Fishman Professor and Head of the Laboratory of Chromatin Biology at The Rockefeller University in New York City. His laboratory focuses on chromatin signaling events related to the 'histone code'.

Thomas Jenuwein is a Senior Scientist at the Research Institute of Molecular Pathology (Vienna) and an Honorary Professor of Genetics at Vienna University. His seminal contributions to the field of epigenetics deal with the regulation of mammalian chromatin by histone methylation.

Danny Reinberg is currently a Professor of Biochemistry at New York University School of Medicine. Before taking his present position, he was a Distinguished University Professor the University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School.

Marie-Laure Caparros is a freelance writer and project manager specializing in epigenetics.

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Home A Genetic Switch An Introduction to Nervous Systems Epigenetics From a to α Genes and Signals Transcriptional Regulation Help