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Footnote #2

Aggarwal A.K. 1995. Structure and function of restriction endonucleases. Curr. Opin. Struct. Biol. 5: 11–19.

Perona J.J. and Craik C.S. 1995. Structural basis of substrate specificity in the serine proteases. Protein Sci. 4: 337–360.

Branden C. and Tooze J. 1999. Introduction to protein structure, 2nd edition. Garland Publishing, New York.

Footnote #3
The footnote is not correct. The over-expressed fragment was actually the F-box alone fused to b-galactosidase. This fragment (not the one described in the footnote) inhibited proteolysis, as expected were it to titrate the F-box binding site on the ubuiquitylating machinery.

Zhou P., Bogacki R., McReynolds L., and Howley P.M. 2000. Harnessing the ubiquitination machinery to target the degradation of specific cellular proteins. Mol. Cell 6: 751–756.

Zhou P. and Howley P.M. 1998. Ubiquitination and degradation of the substrate recognition subunits of SCF ubiquitin-protein ligases. Mol. Cell 2: 571–580.

Footnote #4
Rombel I., North A., Hwang I., Wyman C., and Kustu S. 1998. The bacterial enhancer-binding protein NtrC as a molecular machine. Cold Spring Harbor Symp. Quant. Biol. 63: 157–166.

Footnote #5
Fisher R.P. 1997. CDKs and cyclins in transition(s). Curr. Opin. Genet. Dev. 7: 32–38.

Larochelle S. and Fisher R. 2002. Drosophila CDK7: A paradigm for CAK in metazoans. In The CDK-activating kinase (ed. P. Kaldis). R.G. Landes, Austin, Texas. (In press.)

Footnote #6
Darnell J.E., Jr. 1997. STATs and gene regulation. Science 277: 1630–1635.

Footnote #7
Austin D.J., Crabtree G.R., and Schreiber S.L. 1994. Proximity versus allostery: The role of regulated protein dimerization in biology. Chem. Biol. 1: 131–136.

Footnote #8
Gutkind J.S., Ed. 2000. Signaling networks and cell cycle control: The molecular basis of cancer. Humana Press, Totowa, New Jersey.

Footnote #9
Thomas S.M. and Brugge J.S. 1997. Cellular functions regulated by Src family kinases. Annu. Rev. Cell Dev. Biol. 13: 513–609.

Footnote #10
Van Vactor D., O'Reilly A.M., and Neel B.G. 1998. Genetic analysis of protein tyrosine phosphatases. Curr. Opin. Genet. Dev. 8: 112–126.

Footnote #11
Yaffe M.B., Leparc G.G., Lai J., Obata T., Volinia S., and Cantley L.C. 2001. A motif-based profile scanning approach for genome-wide prediction of signaling pathways. Nat. Biotechnol. 19: 348–353.

Footnote #12
Bromberg J.F., Wrzeszczynska M.H., Devgan G., Zhao Y., Pestell R.G., Albanese C., and Darnell J.E., Jr. 1999. Stat3 as an oncogene (erratum in Cell [1999] 99: 239). Cell 98: 295–303.

Footnote #13
Raff R.A. 1996. The shape of life: Genes, development, and the evolution of animal form. University of Chicago Press, Chicago, Illinois.

Footnote #14
Little J.W., Shepley D.P., and Wert D.W. 1999. Robustness of a gene regulatory circuit. EMBO J. 18: 4299–4307.

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